Gene

glrx3

ID

ZDB-GENE-041010-22

Name

glutaredoxin 3

Symbol

glrx3 Nomenclature History

Previous Names

Grx3 (1)
txnl2 (1)
wu:fb38e09
zgc:103648

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable iron-sulfur cluster binding activity; metal ion binding activity; and protein-disulfide reductase activity. Acts upstream of or within hemoglobin metabolic process and iron ion homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in brain; eye; heart; and intermediate cell mass of mesoderm. Orthologous to human GLRX3 (glutaredoxin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103648 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Haunhorst et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With glrx3 Human Ortholog

No data available

Associated With glrx3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002109	Glutaredoxin
Domain	IPR013766	Thioredoxin domain
Domain	IPR033658	Glutaredoxin, PICOT-like
Family	IPR004480	Monothiol glutaredoxin-related
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily