Gene
mep1a.2
- ID
- ZDB-GENE-041001-208
- Name
- meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2
- Symbol
- mep1a.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Involved in positive regulation of angiogenesis. Predicted to localize to integral component of membrane. Is expressed in several structures, including epidermis; gill; heart; liver; and pleuroperitoneal region. Orthologous to human MEP1A (meprin A subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Schütte et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR001506 | Peptidase M12A |
| Domain | IPR002083 | MATH/TRAF domain |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Family | IPR008294 | Meprin alpha/beta subunit |
| Homologous_superfamily | IPR008974 | TRAF-like |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | MAM domain | MATH/TRAF domain | Meprin alpha/beta subunit | Metallopeptidase, catalytic domain superfamily | Peptidase M12A | Peptidase, metallopeptidase | TRAF-like |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DKP9
|
689 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mep1a.2-201
(1)
|
Ensembl | 2,396 nt | ||
| mRNA |
mep1a.2-202
(1)
|
Ensembl | 2,694 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mep1a.2 | polyclonal |
|
1 |
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- This gene and mep1a.1 (ZDB-GENE-041001-209) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human MEP1A and mouse Mep1a based on amino acid identity and conserved location.