Gene

lhb

ID

ZDB-GENE-040806-2

Name

luteinizing hormone subunit beta

Symbol

lhb Nomenclature History

Previous Names

LHB
Gth II
gthII
LH Beta
zgc:92312

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Enables hormone activity. Acts upstream of or within several processes, including female gamete generation; female gonad development; and spermatogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including endocrine system; female organism; kidney; liver; and male organism. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Orthologous to several human genes including LHB (luteinizing hormone subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

54 figures from 37 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lhb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypogonadotropic hypogonadism 23 with or without anosmia	Alliance	Hypogonadotropic hypogonadism 23 with or without anosmia	228300

Associated With lhb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018245	Gonadotropin, beta subunit, conserved site
Domain	IPR006208	Glycoprotein hormone subunit beta
Family	IPR001545	Gonadotropin, beta subunit
Homologous_superfamily	IPR029034	Cystine-knot cytokine