Gene

socs1a

ID

ZDB-GENE-040801-205

Name

suppressor of cytokine signaling 1a

Symbol

socs1a Nomenclature History

Previous Names

socs1 (1)
zgc:91868

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Involved in several processes, including embryonic hemopoiesis; positive regulation of T cell migration; and regulation of signal transduction. Predicted to localize to phosphatidylinositol 3-kinase complex. Used to study fatty liver disease and hyperinsulinism. Human ortholog(s) of this gene implicated in ovarian carcinoma; prostate cancer; and urinary bladder cancer. Is expressed in several structures, including brain; digestive system; musculature system; pleuroperitoneal region; and visual system. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91868 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With socs1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Autoinflammatory syndrome, familial, with or without immunodeficiency	619375

Associated With socs1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
steatotic liver disease	socs1a^ihb33/ihb33 (AB)	standard conditions	Dai et al., 2015
steatotic liver disease	socs1a^ihb29/ihb29 (AB)	standard conditions	Dai et al., 2015
hyperinsulinism	socs1a^ihb33/+ (AB)	standard conditions	Dai et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR001496	SOCS box domain
Domain	IPR035861	SOCS1, SH2 domain
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	SH2 domain	SH2 domain superfamily	SOCS1, SH2 domain	SOCS box domain
UniProtKB:Q6DEF9 InterPro	201

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	socs1a-201 (1) Ensembl	Ensembl		1,154 nt	Select Tool
mRNA	socs1a-202 (1) Ensembl	Ensembl		642 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-socs1a	polyclonal	socs1a		Rabbit			1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations