Gene
sirt5
- ID
- ZDB-GENE-040718-349
- Name
- sirtuin 5
- Symbol
- sirt5 Nomenclature History
- Previous Names
-
- zgc:92288
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables acyl binding activity and heterocyclic compound binding activity. Predicted to be involved in peptidyl-lysine demalonylation; peptidyl-lysine desuccinylation; and regulation of ketone biosynthetic process. Predicted to be located in cytosol and mitochondrion. Predicted to be active in nucleus. Is expressed in liver and retina. Orthologous to human SIRT5 (sirtuin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92288 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gut et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR026590 | Sirtuin family, catalytic core domain |
| Family | IPR003000 | Sirtuin family |
| Family | IPR027546 | Sirtuin, class III |
| Family | IPR050134 | NAD-dependent sirtuin protein deacylases |
| Homologous_superfamily | IPR026591 | Sirtuin, catalytic core small domain superfamily |
| Homologous_superfamily | IPR029035 | DHS-like NAD/FAD-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin, catalytic core small domain superfamily | Sirtuin, class III | Sirtuin family | Sirtuin family, catalytic core domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BHG7
|
277 | ||||||
|
UniProtKB:Q6DHI5
|
305 |
Interactions and Pathways
No data available
Plasmids
No data available