Gene

gbp1

ID

ZDB-GENE-040718-32

Name

guanylate binding protein 1

Symbol

gbp1 Nomenclature History

Previous Names

wu:fd36d06
zgc:92185 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within thyroid gland development. Is expressed in thyroid follicle. Orthologous to several human genes including GBP1 (guanylate binding protein 1); GBP2 (guanylate binding protein 2); and GBP3 (guanylate binding protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Yang et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gbp1 Human Ortholog

No data available

Associated With gbp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003191	Guanylate-binding protein/Atlastin, C-terminal
Domain	IPR015894	Guanylate-binding protein, N-terminal
Domain	IPR030386	GB1/RHD3-type guanine nucleotide-binding (G) domain
Domain	IPR037684	Guanylate-binding protein, C-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036543	Guanylate-binding protein, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	GB1/RHD3-type guanine nucleotide-binding (G) domain	Guanylate-binding protein/Atlastin, C-terminal	Guanylate-binding protein, C-terminal	Guanylate-binding protein, C-terminal domain superfamily	Guanylate-binding protein, N-terminal	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q6DHP7 InterPro	621

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gbp1-201 (1) Ensembl	Ensembl	2,343 nt	Select Tool ZFIN BLAST
mRNA	gbp1-203 (1) Ensembl	Ensembl	650 nt	Select Tool ZFIN BLAST
ncRNA	gbp1-003 (1) Ensembl	Ensembl	775 nt	Select Tool ZFIN BLAST
ncRNA	gbp1-004 (1) Ensembl	Ensembl	902 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-gbp1	polyclonal	gbp1	IgG	Rabbit	IHC	Sigma-Aldrich	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations