Gene
egfl6
- ID
- ZDB-GENE-040718-157
- Name
- EGF-like-domain, multiple 6
- Symbol
- egfl6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables integrin binding activity and receptor ligand activity. Involved in positive regulation of cell migration involved in sprouting angiogenesis and regulation of sprouting angiogenesis. Acts upstream of or within several processes, including intracellular signal transduction; positive regulation of sprouting angiogenesis; and regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including fin; median fin fold; pharyngeal arch; rhombomere; and somite. Orthologous to human EGFL6 (EGF like domain multiple 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb3 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR052235 | Nephronectin domain-containing protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | MAM domain | Nephronectin domain-containing protein | NOTCH1 EGF-like calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DHG1
|
508 | |||||||||
|
UniProtKB:A0A8M6Z078
|
539 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance