Gene

havcr1

ID

ZDB-GENE-040718-131

Name

hepatitis A virus cellular receptor 1

Symbol

havcr1 Nomenclature History

Previous Names

DrTIM-4 (1)
kim1 (1)
kim4 (1)
TIM-1 (1)
Tim-4 (1)
timd1 (1)
wu:fb01b10 (1)
zgc:92647 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Involved in cytoskeletal rearrangement involved in phagocytosis, engulfment and engulfment of apoptotic cell. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in atopic dermatitis. Is expressed in macrophage. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92647 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Kuil et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With havcr1 Human Ortholog

No data available

Associated With havcr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin domain subtype	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin V-set domain
UniProtKB:Q6DH50 InterPro	264
UniProtKB:A0A2R8QGQ2 InterPro	324
UniProtKB:A0A1C6ZYS3 InterPro	295
UniProtKB:A0A8M9PI76 InterPro	294
UniProtKB:A0A8M3B4U0 InterPro	323
UniProtKB:A0A8M3AMA9 InterPro	323

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	havcr1-201 (1) Ensembl	Ensembl	1,004 nt	Select Tool
mRNA	havcr1-202 (1) Ensembl	Ensembl	917 nt	Select Tool
mRNA	havcr1-203 (1) Ensembl	Ensembl	910 nt	Select Tool
mRNA	havcr1-204 (1) Ensembl	Ensembl	840 nt	Select Tool
mRNA	havcr1-206 (1) Ensembl	Ensembl	3,037 nt	Select Tool ZFIN BLAST
ncRNA	havcr1-005 (1) Ensembl	Ensembl	790 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-havcr	monoclonal	havcr1	IgG2b	Rat	IHC	Novus Biologicals, LLC	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations