Gene

kcnh6a

ID

ZDB-GENE-040702-5

Name

potassium voltage-gated channel, subfamily H (eag-related), member 6a

Symbol

kcnh6a Nomenclature History

Previous Names

kcnh2
kcnh6
bre
breakdance
erg
ether-a-go-go-related (1)
reg
reggae (1)
silent ventricle (1)
unm s213
zerg-3 (1)
zerg (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Enables voltage-gated potassium channel activity. Acts upstream of or within several processes, including heart contraction; membrane repolarization during cardiac muscle cell action potential; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; gill; immune system; and muscle. Used to study long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 30 figures from 14 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnh6a Human Ortholog

No data available

Associated With kcnh6a Via Experimental Models

Human Disease	Fish	Conditions	Citations
long QT syndrome	kcnh6a^tb218/tb218	standard conditions	Bezzerides et al., 2017
long QT syndrome	kcnh6a^s290/+	standard conditions	Arnaout et al., 2007
long QT syndrome 2	nkhspGFF3AEt + MO1-kcnh6a	standard conditions	Tanaka et al., 2018
short QT syndrome	kcnh6a^m230/m230	standard conditions	Hassel et al., 2008

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000014	PAS domain
Domain	IPR000595	Cyclic nucleotide-binding domain
Domain	IPR005821	Ion transport domain
Family	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG-like
Family	IPR003967	Potassium channel, voltage-dependent, ERG
Family	IPR050818	Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily
Homologous_superfamily	IPR035965	PAS domain superfamily

Domain Details Per Protein

Protein	Length	Cyclic nucleotide-binding domain	Cyclic nucleotide-binding domain superfamily	Ion transport domain	PAS domain	PAS domain superfamily	Potassium channel, voltage-dependent, EAG/ELK/ERG-like	Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type	Potassium channel, voltage-dependent, ERG	RmlC-like jelly roll fold
UniProtKB:A0A8M2BBD6 InterPro	1185
UniProtKB:A0A8M3AQY1 InterPro	856
UniProtKB:Q8JH78 InterPro	1186
UniProtKB:A0A8M2BBB6 InterPro	915

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kcnh6a-201 (1) Ensembl	Ensembl		4,583 nt	Select Tool ZFIN BLAST
mRNA	kcnh6a-202 (1) Ensembl	Ensembl		4,931 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Deleted orthology to KCNH2 from Lagenheinrich et al (2003) based on new orthology information in Leong et al (2010). Assigned orthology to KCNH6 based on synteny presented in Leong et al.

Citations