Gene
nlk1
- ID
- ZDB-GENE-040701-1
- Name
- nemo-like kinase, type 1
- Symbol
- nlk1 Nomenclature History
- Previous Names
-
- nlk
- nlkb
- zgc:111875
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and MAP kinase activity. Involved in negative regulation of Notch signaling pathway; positive regulation of Wnt signaling pathway; and positive regulation of neurogenesis. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including eye; immature eye; neural plate; notochord; and otic vesicle. Orthologous to human NLK (nemo like kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ishitani et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR003527 | Mitogen-activated protein (MAP) kinase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050117 | Mitogen-activated protein kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Mitogen-activated protein kinase | Mitogen-activated protein (MAP) kinase, conserved site | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6Q382
|
475 |
Interactions and Pathways
Plasmids