Gene
rb1
- ID
- ZDB-GENE-040428-1
- Name
- retinoblastoma 1
- Symbol
- rb1 Nomenclature History
- Previous Names
-
- spc
- zgc:154147
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have RNA polymerase II activating transcription factor binding activity and RNA polymerase II regulatory region DNA binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nervous system development; and visual perception. Predicted to localize to Rb-E2F complex and chromatin. Used to study cancer. Human ortholog(s) of this gene implicated in nervous system cancer (multiple); osteosarcoma; prostate cancer; small cell carcinoma; and urinary bladder cancer. Is expressed in oocyte stage I; retina; and testis. Orthologous to human RB1 (RB transcriptional corepressor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lung small cell carcinoma | Alliance | Small cell cancer of the lung, somatic | 182280 |
| osteosarcoma | Alliance | Osteosarcoma, somatic | 259500 |
| retinoblastoma | Alliance | Retinoblastoma | 180200 |
| retinoblastoma | Alliance | Retinoblastoma, trilateral | 180200 |
| urinary bladder cancer | Alliance | Bladder cancer, somatic | 109800 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cancer | WIK + TALEN3-rb1 | standard conditions | Solin et al., 2015 |
| cancer | WIK + TALEN2-rb1 | standard conditions | Solin et al., 2015 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002719 | Retinoblastoma-associated protein, B-box |
| Domain | IPR002720 | Retinoblastoma-associated protein, A-box |
| Domain | IPR015030 | Retinoblastoma-associated protein, C-terminal |
| Domain | IPR024599 | Retinoblastoma-associated protein, N-terminal |
| Family | IPR028309 | Retinoblastoma protein family |
| Homologous_superfamily | IPR036915 | Cyclin-like superfamily |
Domain Details Per Protein
| Protein | Length | Cyclin-like superfamily | Retinoblastoma-associated protein, A-box | Retinoblastoma-associated protein, B-box | Retinoblastoma-associated protein, C-terminal | Retinoblastoma-associated protein, N-terminal | Retinoblastoma protein family |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0JMQ4
|
903 |
Interactions and Pathways
No data available
Plasmids
No data available