Gene
unga
- ID
- ZDB-GENE-040426-900
- Name
- uracil DNA glycosylase a
- Symbol
- unga Nomenclature History
- Previous Names
-
- ung
- zgc:56102 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables G/U mismatch-specific uracil-DNA glycosylase activity and histone H3K27 methyltransferase activity. Acts upstream of or within positive regulation of DNA-templated transcription and regulation of DNA methylation. Predicted to be active in mitochondrion and nucleus. Is expressed in blastomere; oocyte stage I; and oocyte stage II. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56102 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency with hyper IgM type 5 | Alliance | Immunodeficiency with hyper IgM, type 5 | 608106 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Uracil-DNA glycosylase, active site | Uracil-DNA glycosylase family 1 | Uracil-DNA glycosylase-like | Uracil-DNA glycosylase-like domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZVD1
|
291 | ||||
|
UniProtKB:A0A8M6Z6T9
|
295 |
Interactions and Pathways
No data available
Plasmids
No data available