Gene
tubg1
- ID
- ZDB-GENE-040426-836
- Name
- tubulin, gamma 1
- Symbol
- tubg1 Nomenclature History
- Previous Names
-
- tubgl (1)
- zgc:55894
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have GTP binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Predicted to localize to cytoplasm; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Is expressed in blastomere; oocyte stage III; and oocyte stage V. Orthologous to several human genes including TUBG1 (tubulin gamma 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145281 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complex cortical dysplasia with other brain malformations 4 | Alliance | Cortical dysplasia, complex, with other brain malformations 4 | 615412 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017975 | Tubulin, conserved site |
| Domain | IPR003008 | Tubulin/FtsZ, GTPase domain |
| Domain | IPR018316 | Tubulin/FtsZ, 2-layer sandwich domain |
| Family | IPR000217 | Tubulin |
| Family | IPR002454 | Gamma tubulin |
| Homologous_superfamily | IPR008280 | Tubulin/FtsZ, C-terminal |
| Homologous_superfamily | IPR023123 | Tubulin, C-terminal |
| Homologous_superfamily | IPR036525 | Tubulin/FtsZ, GTPase domain superfamily |
| Homologous_superfamily | IPR037103 | Tubulin/FtsZ-like, C-terminal domain |
Domain Details Per Protein
| Protein | Length | Gamma tubulin | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B0JZL0
|
264 | |||||||||
|
UniProtKB:A0A8M6YXT8
|
261 | |||||||||
|
UniProtKB:Q7ZVM5
|
451 |
Interactions and Pathways
No data available
Plasmids
No data available