Gene

atp2a2a

ID

ZDB-GENE-040426-702

Name

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a

Symbol

atp2a2a Nomenclature History

Previous Names

atp2a2 (1)
serca2 (1)
zgc:55380 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have calcium transmembrane transporter activity, phosphorylative mechanism and proton-exporting ATPase activity, phosphorylative mechanism. Involved in heart looping and regulation of heart contraction. Predicted to localize to sarcoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Is expressed in cardiovascular system; musculature system; pectoral fin; polster; and somite. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 18 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55380 (12 images)
IMAGE:7165932 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ebert et al., 2005
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atp2a2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acrokeratosis verruciformis	Alliance	Acrokeratosis verruciformis	101900
keratosis follicularis	Alliance	Darier disease	124200

Associated With atp2a2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004014	Cation-transporting P-type ATPase, N-terminal
Domain	IPR006068	Cation-transporting P-type ATPase, C-terminal
Domain	IPR044492	P-type ATPase, haloacid dehalogenase domain
Family	IPR001757	P-type ATPase
Family	IPR005782	P-type ATPase, subfamily IIA, SERCA-type
Homologous_superfamily	IPR008250	P-type ATPase, A domain superfamily
Homologous_superfamily	IPR023214	HAD superfamily
Homologous_superfamily	IPR023298	P-type ATPase, transmembrane domain superfamily
Homologous_superfamily	IPR023299	P-type ATPase, cytoplasmic domain N
Homologous_superfamily	IPR036412	HAD-like superfamily
PTM	IPR018303	P-type ATPase, phosphorylation site

Domain Details Per Protein

Protein	Length	Cation-transporting P-type ATPase, C-terminal	Cation-transporting P-type ATPase, N-terminal	HAD-like superfamily	HAD superfamily	P-type ATPase	P-type ATPase, A domain superfamily	P-type ATPase, cytoplasmic domain N	P-type ATPase, haloacid dehalogenase domain	P-type ATPase, phosphorylation site	P-type ATPase, subfamily IIA, SERCA-type	P-type ATPase, transmembrane domain superfamily
UniProtKB:Q7ZW18 InterPro	996
UniProtKB:A0A8M2BEU8 InterPro	1042
UniProtKB:A0A8M9QII7 InterPro	996

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	atp2a2a-202 (1) Ensembl	Ensembl	798 nt	Select Tool
mRNA	atp2a2a-201 (1) Ensembl	Ensembl	3,724 nt	Select Tool
mRNA	atp2a2a-203 (1) Ensembl	Ensembl	3,186 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-atp2a2a	polyclonal	atp2a2a	IgG	Rabbit		GeneTex	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations