Gene

apex1

ID

ZDB-GENE-040426-2761

Name

APEX nuclease (multifunctional DNA repair enzyme) 1

Symbol

apex1 Nomenclature History

Previous Names

hm:zehn1532
wu:fc13d11
zap1 (1)
zgc:66204

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA 3'-5' exodeoxyribonuclease activity; and phosphodiesterase I activity. Involved in several processes, including heart contraction; heart looping; and negative regulation of apoptotic process. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Is expressed in head. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66204 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apex1 Human Ortholog

No data available

Associated With apex1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR020847	AP endonuclease 1, binding site
Conserved_site	IPR020848	AP endonuclease 1, conserved site
Domain	IPR005135	Endonuclease/exonuclease/phosphatase
Family	IPR004808	AP endonuclease 1
Homologous_superfamily	IPR036691	Endonuclease/exonuclease/phosphatase superfamily

Domain Details Per Protein

Protein	Length	AP endonuclease 1	AP endonuclease 1, binding site	AP endonuclease 1, conserved site	Endonuclease/exonuclease/phosphatase	Endonuclease/exonuclease/phosphatase superfamily
UniProtKB:A0A8M1PAH1 InterPro	341
UniProtKB:A0A2R9YJQ0 InterPro	310
UniProtKB:A0MTA1 InterPro PDB	310
UniProtKB:A0A8M1P554 InterPro	309
UniProtKB:A0A0R4IWF9 InterPro	340

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	apex1-201 (1) Ensembl	Ensembl	2,119 nt	Select Tool
mRNA	apex1-202 (1) Ensembl	Ensembl	2,139 nt	Select Tool ZFIN BLAST
mRNA	apex1-203 (1) Ensembl	Ensembl	579 nt	Select Tool
mRNA	apex1-204 (1) Ensembl	Ensembl	754 nt	Select Tool
mRNA	apex1-205 (1) Ensembl	Ensembl	388 nt	Select Tool
mRNA	apex1-206 (1) Ensembl	Ensembl	682 nt	Select Tool
mRNA	apex1-207 (1) Ensembl	Ensembl	709 nt	Select Tool
mRNA	apex1-208 (1) Ensembl	Ensembl	2,136 nt	Select Tool ZFIN BLAST
mRNA	apex1-209 (1) Ensembl	Ensembl	2,690 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-apex1	polyclonal	apex1		Rabbit	WB		3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations