Gene

srsf2a

ID

ZDB-GENE-040426-2706

Name

serine and arginine rich splicing factor 2a

Symbol

srsf2a Nomenclature History

Previous Names

sfrs2
srsf2
hm:zeh0252
wu:fb51a05
wu:fk59b08
zgc:56283

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including SRSF2 (serine and arginine rich splicing factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56283 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With srsf2a Human Ortholog

No data available

Associated With srsf2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR003954	RNA recognition motif domain, eukaryote
Family	IPR051106	RNA-binding and splicing regulatory protein
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding and splicing regulatory protein	RNA-binding domain superfamily	RNA recognition motif domain	RNA recognition motif domain, eukaryote
UniProtKB:Q7ZV13 InterPro	225

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	srsf2a-202 (1) Ensembl	Ensembl	582 nt	Select Tool ZFIN BLAST
aberrant processed transcript	srsf2a-205 (1) Ensembl	Ensembl	567 nt	Select Tool ZFIN BLAST
aberrant processed transcript	srsf2a-206 (1) Ensembl	Ensembl	603 nt	Select Tool ZFIN BLAST
aberrant processed transcript	srsf2a-208 (1) Ensembl	Ensembl	908 nt	Select Tool ZFIN BLAST
mRNA	srsf2a-201 (1) Ensembl	Ensembl	1,776 nt	Select Tool ZFIN BLAST
mRNA	srsf2a-204 (1) Ensembl	Ensembl	1,151 nt	Select Tool ZFIN BLAST
mRNA	srsf2a-207 (1) Ensembl	Ensembl	855 nt	Select Tool ZFIN BLAST
mRNA	srsf2a-209 (1) Ensembl	Ensembl	707 nt	Select Tool ZFIN BLAST
mRNA	srsf2a-211 (1) Ensembl	Ensembl	788 nt	Select Tool ZFIN BLAST
ncRNA	srsf2a-002 (1) Ensembl	Ensembl	1,024 nt	Select Tool ZFIN BLAST
ncRNA	srsf2a-010 (1) Ensembl	Ensembl	636 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations