Gene

ddc

ID

ZDB-GENE-040426-2656

Name

dopa decarboxylase

Symbol

ddc Nomenclature History

Previous Names

aromatic amino acid decarboxylase (1)
wu:fa56d05
wu:fd59h03
wu:fk20h01
zgc:65801 (1)
zgc:76929 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have carboxy-lyase activity and pyridoxal phosphate binding activity. Involved in brain development. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Is expressed in digestive system; muscle; nervous system; ovary; and pharyngeal arch. Orthologous to human DDC (dopa decarboxylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:76929 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Shih et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddc Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
aromatic L-amino acid decarboxylase deficiency	Alliance	Aromatic L-amino acid decarboxylase deficiency	608643

Associated With ddc Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR021115	Pyridoxal-phosphate binding site
Family	IPR002129	Pyridoxal phosphate-dependent decarboxylase
Family	IPR010977	Aromatic-L-amino-acid decarboxylase
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase