Gene
mre11a
- ID
- ZDB-GENE-040426-2638
- Name
- MRE11 homolog A, double strand break repair nuclease
- Symbol
- mre11a Nomenclature History
- Previous Names
-
- fc38f05
- wu:faa63d12
- wu:fc38f05
- zgc:64018
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in mitotic DNA damage checkpoint signaling and nucleic acid metabolic process. Predicted to act upstream of or within double-strand break repair and meiotic cell cycle. Predicted to be located in nucleus. Predicted to be part of Mre11 complex. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Human ortholog(s) of this gene implicated in Lynch syndrome; breast carcinoma; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64018 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia-telangiectasia-like disorder-1 | Alliance | Ataxia-telangiectasia-like disorder 1 | 604391 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004843 | Calcineurin-like phosphoesterase domain, ApaH type |
| Domain | IPR007281 | Mre11, DNA-binding |
| Family | IPR003701 | DNA double-strand break repair protein Mre11 |
| Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
| Homologous_superfamily | IPR038487 | Mre11, capping domain |
Domain Details Per Protein
| Protein | Length | Calcineurin-like phosphoesterase domain, ApaH type | DNA double-strand break repair protein Mre11 | Metallo-dependent phosphatase-like | Mre11, capping domain | Mre11, DNA-binding |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QPT3
|
700 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mre11a-201
(1)
|
Ensembl | 2,157 nt | ||
| mRNA |
mre11a-202
(1)
|
Ensembl | 5,935 nt |
Interactions and Pathways
No data available
Plasmids
No data available