Gene

rbfox2

ID

ZDB-GENE-040426-2464

Name

RNA binding fox-1 homolog 2

Symbol

rbfox2 Nomenclature History

Previous Names

rbm9
zgc:85694

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have mRNA binding activity. Involved in cardiac muscle fiber development; regulation of RNA splicing; and skeletal muscle fiber development. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including muscle; pectoral fin bud; segmental plate; skeletal muscle satellite cell; and tail bud. Orthologous to human RBFOX2 (RNA binding fox-1 homolog 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Martin et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rbfox2 Human Ortholog

No data available

Associated With rbfox2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR025670	Fox-1 C-terminal domain
Domain	IPR034237	FOX1, RNA recognition motif
Family	IPR017325	RNA binding protein fox-1 homolog 1-3
Family	IPR047131	RNA binding protein fox-1 homolog 1-like
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Fox-1 C-terminal domain	FOX1, RNA recognition motif	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA binding protein fox-1 homolog 1-3	RNA binding protein fox-1 homolog 1-like	RNA recognition motif domain
UniProtKB:A0A8M9Q615 InterPro	358
UniProtKB:A0A8M9PZL7 InterPro	392
UniProtKB:Q6NV06 InterPro	241
UniProtKB:A0A8M9QFB1 InterPro	247
UniProtKB:A0A8M9PM01 InterPro	425
UniProtKB:A0A8M9QA95 InterPro	425

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	rbfox2-201 (1) Ensembl	Ensembl		3,274 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-rbfox2	polyclonal	rbfox2		Rabbit	IHC		3

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations