Gene
igfbp7
- ID
- ZDB-GENE-040426-2423
- Name
- insulin-like growth factor binding protein 7
- Symbol
- igfbp7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Exhibits identical protein binding activity. Involved in branching involved in blood vessel morphogenesis and sprouting angiogenesis. Predicted to localize to extracellular region. Is expressed in several structures, including cardiovascular system; central nervous system; hypochord; notochord; and pleuroperitoneal region. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85888 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Hooper et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Retinal arterial macroaneurysm with supravalvular pulmonic stenosis | 614224 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Family | IPR011390 | Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25 |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25 | Kazal domain | Kazal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NW92
|
257 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igfbp7-201
(1)
|
Ensembl | 869 nt | ||
| mRNA |
igfbp7-202
(1)
|
Ensembl | 813 nt |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-igfbp7 | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available