Gene

elmo1

ID

ZDB-GENE-040426-2069

Name

engulfment and cell motility 1 (ced-12 homolog, C. elegans)

Symbol

elmo1 Nomenclature History

Previous Names

im:7151147
wu:fq24e08
zgc:85612 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Involved in cilium assembly; lymphangiogenesis; and positive regulation of angiogenesis. Is expressed in several structures, including blood vessel; immature eye; mesoderm; nervous system; and pronephric tubule. Orthologous to human ELMO1 (engulfment and cell motility 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

29 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147174 (1 image)
IMAGE:7151147 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 24 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With elmo1 Human Ortholog

No data available

Associated With elmo1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR006816	ELMO domain
Domain	IPR024574	ELMO, armadillo-like helical domain
Family	IPR050868	Engulfment and cell motility domain-containing protein
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	ELMO, armadillo-like helical domain	ELMO domain	Engulfment and cell motility domain-containing protein	PH-like domain superfamily	Pleckstrin homology domain
UniProtKB:A0A8M6YUG7 InterPro	521
UniProtKB:A0A8M3ASM6 InterPro	714
UniProtKB:A0A2R8RS12 InterPro	728
UniProtKB:Q6NV39 InterPro	726
UniProtKB:A0A8M3AVM1 InterPro	247
UniProtKB:A0A8M3ASM3 InterPro	740

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	elmo1-201 (1) Ensembl	Ensembl	2,445 nt	Select Tool ZFIN BLAST
mRNA	elmo1-202 (1) Ensembl	Ensembl	784 nt	Select Tool
mRNA	elmo1-205 (1) Ensembl	Ensembl	3,398 nt	Select Tool
mRNA	elmo1-206 (1) Ensembl	Ensembl	2,409 nt	Select Tool ZFIN BLAST
ncRNA	elmo1-002 (1) Ensembl	Ensembl	962 nt	Select Tool
ncRNA	elmo1-004 (1) Ensembl	Ensembl	310 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-elmo1	polyclonal	elmo1		Goat	WB	Everest Biotech	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations