Gene
becn1
- ID
- ZDB-GENE-040426-1666
- Name
- beclin 1, autophagy related
- Symbol
- becn1 Nomenclature History
- Previous Names
-
- zgc:73097
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; cellular senescence; and regulation of skeletal muscle tissue regeneration. Predicted to be located in several cellular components, including autophagosome; endosome membrane; and mitochondrial membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. Is expressed in several structures, including blastoderm; blastomere; digestive system; muscle; and retina. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to several human genes including BECN1 (beclin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hepatocellular carcinoma | becn1hza56/+ (AB) | standard conditions | Mawed et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Atg6, BARA domain | Atg6/Beclin | Atg6/beclin, coiled-coil domain | Atg6/Beclin C-terminal domain superfamily | Beclin-1, BH3 domain |
|---|---|---|---|---|---|---|
|
UniProtKB:F1RCP1
|
447 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-becn1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
7 |
Plasmids
No data available