Gene

pde6c

ID

ZDB-GENE-040426-1664

Name

phosphodiesterase 6C, cGMP-specific, cone, alpha prime

Symbol

pde6c Nomenclature History

Previous Names

eclipse (1)
pde6 alpha prime (1)
zgc:73085

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and metal ion binding activity. Acts upstream of or within embryonic retina morphogenesis in camera-type eye; photoreceptor cell maintenance; and visual perception. Is expressed in head and visual system. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Orthologous to human PDE6C (phosphodiesterase 6C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pde6c Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cone dystrophy 4	613093

Associated With pde6c Via Experimental Models

Human Disease	Fish	Conditions	Citations
retinal degeneration	pde6c^w59/w59	standard conditions	(3)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain	IPR003018	GAF domain
Domain	IPR003607	HD/PDEase domain
Family	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily	IPR029016	GAF-like domain superfamily
Homologous_superfamily	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily