Gene

ilk

ID

ZDB-GENE-040426-1435

Name

integrin-linked kinase

Symbol

ilk Nomenclature History

Previous Names

loc
lost-contact
main squeeze
msq
zgc:65842
zilk (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Exhibits protein kinase activity. Involved in several processes, including circulatory system development; muscle attachment; and tendon development. Localizes to Z disc and sarcolemma. Predicted to colocalize with stress fiber. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in brain; cardiovascular system; muscle; myoblast; and somite. Orthologous to human ILK (integrin linked kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:65842 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ilk Human Ortholog

No data available

Associated With ilk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR035692	Integrin-linked protein kinase, pseudokinase domain
Family	IPR050167	Serine/threonine-protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Integrin-linked protein kinase, pseudokinase domain	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase	Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:Q6PHD6 InterPro	452

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ilk-201 (1) Ensembl	Ensembl	3,200 nt	Select Tool
mRNA	ilk-203 (1) Ensembl	Ensembl	6,066 nt	Select Tool ZFIN BLAST
ncRNA	ilk-002 (1) Ensembl	Ensembl	803 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ilk	monoclonal	ilk	IgG2b	Mouse	IHC WB	Millipore	3
Ab2-ilk	polyclonal	ilk	IgG	Rabbit	IHC	GeneTex	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations