Gene
prkcbb
- ID
- ZDB-GENE-040426-1178
- Name
- protein kinase C, beta b
- Symbol
- prkcbb Nomenclature History
- Previous Names
-
- prkcb1
- zgc:63591 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have several functions, including androgen receptor binding activity; histone kinase activity (H3-T6 specific); and nuclear receptor transcription coactivator activity. Involved in blood coagulation and embryonic hemopoiesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Is expressed in brain; retinal neural layer; and somite border. Orthologous to human PRKCB (protein kinase C beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Domain | IPR034664 | Classical protein kinase C beta, catalytic domain |
| Family | IPR014375 | Protein kinase C, alpha/beta/gamma types |
| Family | IPR050236 | Serine/threonine-protein kinases, AGC |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | C1-like domain superfamily | C2 domain | C2 domain superfamily | Classical protein kinase C beta, catalytic domain | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C, alpha/beta/gamma types | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QMW2
|
670 | ||||||||||||||
|
UniProtKB:Q7SY24
|
670 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkcbb-201
(1)
|
Ensembl | 4,340 nt | ||
| mRNA |
prkcbb-202
(1)
|
Ensembl | 4,732 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-prkcb1 | monoclonal | IgG1 | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
5 | |
| Ab2-prkcb1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available