Gene

arl6ip1

ID

ZDB-GENE-040426-1087

Name

ARL6 interacting reticulophagy regulator 1

Symbol

arl6ip1 Nomenclature History

Previous Names

arl6ip (1)
zgc:56593 (1)
zgc:77873

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Acts upstream of or within neural crest cell migration and retina morphogenesis in camera-type eye. Predicted to be part of Sec61 translocon complex. Predicted to be active in membrane. Is expressed in several structures, including blastodisc; central nervous system; hypochord; optic cup; and retina. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7140611 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 20 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arl6ip1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary spastic paraplegia 61	Alliance	Spastic paraplegia 61, autosomal recessive	615685

Associated With arl6ip1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR052114	ER-associated autophagy and membrane dynamics regulator

Domain Details Per Protein

Protein	Length	ER-associated autophagy and membrane dynamics regulator
UniProtKB:Q7ZWB4 InterPro	203

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arl6ip1-201 (1) Ensembl	Ensembl	1,590 nt	Select Tool ZFIN BLAST
mRNA	arl6ip1-202 (1) Ensembl	Ensembl	615 nt	Select Tool ZFIN BLAST
ncRNA	arl6ip1-003 (1) Ensembl	Ensembl	781 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-arl6ip1	polyclonal	arl6ip1	IgG	Rabbit	WB	Abcam plc	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations