Gene

usf1

ID

ZDB-GENE-040426-1072

Name

upstream transcription factor 1

Symbol

usf1 Nomenclature History

Previous Names

zgc:56547

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in cardiovascular system disease and type 2 diabetes mellitus. Orthologous to human USF1 (upstream transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56547 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Hyperlipidemia, familial combined, susceptibility to}	602491

Associated With usf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Family	IPR051732	Upstream Stimulatory Factor
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	Myc-type, basic helix-loop-helix (bHLH) domain	Upstream Stimulatory Factor
UniProtKB:Q7ZWC6 InterPro	309
UniProtKB:A0A8M9QLB1 InterPro	303
UniProtKB:A0A8M3B0Z9 InterPro	297
UniProtKB:F1QUA1 InterPro	309
UniProtKB:A0A8M9Q076 InterPro	293
UniProtKB:A0A8M2B3M5 InterPro	288
UniProtKB:A0A8M3APR4 InterPro	307
UniProtKB:A0A8M2B4D0 InterPro	299
UniProtKB:A0A8M2B4B2 InterPro	298

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	usf1-207 (1) Ensembl	Ensembl	1,450 nt	Select Tool ZFIN BLAST
mRNA	usf1-201 (1) Ensembl	Ensembl	1,492 nt	Select Tool ZFIN BLAST
mRNA	usf1-202 (1) Ensembl	Ensembl	710 nt	Select Tool ZFIN BLAST
mRNA	usf1-203 (1) Ensembl	Ensembl	402 nt	Select Tool ZFIN BLAST
mRNA	usf1-204 (1) Ensembl	Ensembl	931 nt	Select Tool ZFIN BLAST
mRNA	usf1-205 (1) Ensembl	Ensembl	579 nt	Select Tool ZFIN BLAST
mRNA	usf1-206 (1) Ensembl	Ensembl	832 nt	Select Tool ZFIN BLAST
mRNA	usf1-208 (1) Ensembl	Ensembl	765 nt	Select Tool ZFIN BLAST
mRNA	usf1-209 (1) Ensembl	Ensembl	805 nt	Select Tool ZFIN BLAST
mRNA	usf1-210 (1) Ensembl	Ensembl	838 nt	Select Tool ZFIN BLAST
mRNA	usf1-211 (1) Ensembl	Ensembl	2,868 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations