Gene
fus
- ID
- ZDB-GENE-040426-1010
- Name
- FUS RNA binding protein
- Symbol
- fus Nomenclature History
- Previous Names
-
- zgc:56390 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity and transcription coregulator activity. Involved in axon extension. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Is expressed in brain; eye; hindbrain; somite; and spinal cord. Orthologous to human FUS (FUS RNA binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 6 | Alliance | Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia | 608030 |
| essential tremor 4 | Alliance | Essential tremor, hereditary, 4 | 614782 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| amyotrophic lateral sclerosis | fussa15506/sa15506 | standard conditions | Bourefis et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR001876 | Zinc finger, RanBP2-type |
| Family | IPR034870 | TAF15/EWS/TLS family |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036443 | Zinc finger, RanBP2-type superfamily |
Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | TAF15/EWS/TLS family | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R0M4
|
541 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-fus | monoclonal | IgG1 | Mouse |
|
BD Biosciences
|
2 |
Plasmids
No data available