Gene
psenen
- ID
- ZDB-GENE-040218-1
- Name
- presenilin enhancer, gamma-secretase subunit
- Symbol
- psenen Nomenclature History
- Previous Names
-
- pen2 (1)
- zgc:109727
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Involved in developmental pigmentation; melanocyte migration; and negative regulation of neuron apoptotic process. Predicted to localize to gamma-secretase complex and integral component of membrane. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Is expressed in forebrain; hindbrain; midbrain; presumptive neural retina; and trunk. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109727 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hidradenitis suppurativa | Alliance | Acne inversa, familial, 2, with or without Dowling-Degos disease | 613736 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019379 | Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit |
Domain Details Per Protein
| Protein | Length | Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit |
|---|---|---|
|
UniProtKB:Q8JHF0
|
101 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
psenen-201
(1)
|
Ensembl | 976 nt | ||
| mRNA |
psenen-202
(1)
|
Ensembl | 339 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-psenen | polyclonal |
|
1 |
Plasmids
No data available