Gene
cyp17a1
- ID
- ZDB-GENE-040213-2
- Name
- cytochrome P450, family 17, subfamily A, polypeptide 1
- Symbol
- cyp17a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; 17-alpha-hydroxyprogesterone aldolase activity; and steroid 17-alpha-monooxygenase activity. Acts upstream of or within with a positive effect on female sex determination. Acts upstream of or within with a negative effect on male sex determination. Acts upstream of or within androst-4-ene-3,17-dione biosynthetic process and progesterone metabolic process. Predicted to be located in membrane. Is expressed in brain and endocrine system. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157435 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital adrenal hyperplasia | Alliance | 17,20-lyase deficiency, isolated | 202110 |
| congenital adrenal hyperplasia | Alliance | 17-alpha-hydroxylase/17,20-lyase deficiency | 202110 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:B3DH80
|
519 | ||||
|
UniProtKB:A0A8M1PIC7
|
519 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp17a1-201
(1)
|
Ensembl | 2,799 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cyp17a1 | Rabbit |
|
3 |
Plasmids
No data available