Gene

tardbpa

ID

ZDB-GENE-031030-1

Name

TAR DNA binding protein a

Symbol

tardbpa Nomenclature History

Previous Names

tardbp
tardbpl
wu:fb52e05
wu:fe47c11
wu:fj94b04

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including axon extension; neuromuscular junction development; and skeletal muscle tissue development. Predicted to localize to nucleoplasm and ribonucleoprotein complex. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Is expressed in brain and fin. Orthologous to several human genes including TARDBP (TAR DNA binding protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55467 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tardbpa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
amyotrophic lateral sclerosis type 10	Alliance	Amyotrophic lateral sclerosis 10, with or without FTD	612069
amyotrophic lateral sclerosis type 10	Alliance	Frontotemporal lobar degeneration, TARDBP-related	612069

Associated With tardbpa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR041105	TAR DNA-binding protein 43, N-terminal
Domain	IPR049124	TAR DNA-binding protein 43, C-terminal
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain	TAR DNA-binding protein 43, C-terminal	TAR DNA-binding protein 43, N-terminal
UniProtKB:Q803N5 InterPro	303
UniProtKB:A0A8M9PSZ1 InterPro	396

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	tardbpl-201 (1) Ensembl	Ensembl	1,785 nt	Select Tool
aberrant processed transcript	tardbpl-202 (1) Ensembl	Ensembl	2,244 nt	Select Tool
mRNA	tardbpl-203 (1) Ensembl	Ensembl	1,828 nt	Select Tool
mRNA	tardbpl-204 (1) Ensembl	Ensembl	1,773 nt	Select Tool
mRNA	tardbpl-205 (1) Ensembl	Ensembl	941 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Citations
Ab1-tardbpl	monoclonal	tardbpa	IgG2a	Rat	WB	1
Ab2-tardbpl	monoclonal	tardbpa	IgG2c	Rat		1
Ab3-tardbpl	monoclonal	tardbpa	IgG2a	Rat	WB	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Hewamadduma, et al. (2013. Human molecular genetics 22:2376-86.) suggested this gene was the ortholog of human TARDBPP1 and mouse GM13886 based on conserved location. Subsequent data and analysis supports it being the ortholog of human TARDBP and mouse Tardbp.

Citations