Gene
pck1
- ID
- ZDB-GENE-030909-11
- Name
- phosphoenolpyruvate carboxykinase 1 (soluble)
- Symbol
- pck1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Involved in ion homeostasis and response to glucose. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and yolk syncytial layer. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 68 figures from 47 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb856 (8 images)
- cb924 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Furukawa et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Phosphoenolpyruvate carboxykinase deficiency, cytosolic | 261680 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018091 | Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site |
| Domain | IPR035077 | Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain |
| Domain | IPR035078 | Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal |
| Family | IPR008209 | Phosphoenolpyruvate carboxykinase, GTP-utilising |
| Homologous_superfamily | IPR008210 | Phosphoenolpyruvate carboxykinase, N-terminal |
| Homologous_superfamily | IPR013035 | Phosphoenolpyruvate carboxykinase, C-terminal |
Domain Details Per Protein
| Protein | Length | Phosphoenolpyruvate carboxykinase, C-terminal | Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain | Phosphoenolpyruvate carboxykinase, GTP-utilising | Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site | Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal | Phosphoenolpyruvate carboxykinase, N-terminal |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PZI9
|
630 | ||||||
|
UniProtKB:Q7T3G9
|
630 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pck1 | monoclonal | IgG2a | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available