Gene

gabbr1a

ID

ZDB-GENE-030904-5

Name

gamma-aminobutyric acid (GABA) B receptor, 1a

Symbol

gabbr1a Nomenclature History

Previous Names

gaba1 (1)
gabbr1

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to localize to G protein-coupled receptor heterodimeric complex. Is expressed in female organism; male organism; and nervous system. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gabbr1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with language delay and variable cognitive abnormalities	620502

Associated With gabbr1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR017978	GPCR family 3, C-terminal
Family	IPR002455	GPCR family 3, GABA-B receptor
Family	IPR002456	GPCR family 3, gamma-aminobutyric acid receptor, type B1
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily

Domain Details Per Protein

Protein	Length	GPCR family 3, C-terminal	GPCR family 3, GABA-B receptor	GPCR family 3, gamma-aminobutyric acid receptor, type B1	Periplasmic binding protein-like I	Receptor, ligand binding region	Sushi/SCR/CCP domain	Sushi/SCR/CCP superfamily
UniProtKB:A0A8N7UVF8 InterPro	988

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	gabbr1a-201 (1) Ensembl	Ensembl		3,179 nt	Select Tool ZFIN BLAST
mRNA	gabbr1a-202 (1) Ensembl	Ensembl		2,154 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-gabbr1	polyclonal	gabbr1a	IgG	Goat	IHC WB	Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations