Gene

mmp14a

ID
ZDB-GENE-030901-1
Name
matrix metallopeptidase 14a (membrane-inserted)
Symbol
mmp14a Nomenclature History
Previous Names
  • cb386 (1)
  • MT-MMPalpha
  • sb:cb386 (1)
  • wu:fb72b09
  • zMT-MMP-alpha (1)
  • zMT-MMPalpha
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity and zinc ion binding activity. Involved in several processes, including embryonic morphogenesis; retina layer formation; and retinal ganglion cell axon guidance. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in myocardial infarction. Is expressed in several structures, including axis; head; head mesenchyme; mesoderm; and musculature system. Orthologous to human MMP14 (matrix metallopeptidase 14).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mmp14a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Winchester syndrome Alliance Winchester syndrome 277950
Associated With mmp14a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
Conserved_site IPR018486 Hemopexin, conserved site
Domain IPR000585 Hemopexin-like domain
Domain IPR001818 Peptidase M10, metallopeptidase
Domain IPR002477 Peptidoglycan binding-like
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
Domain IPR033739 Peptidase M10A, catalytic domain
Family IPR021190 Peptidase M10A
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036365 PGBD-like superfamily
Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
Repeat IPR018487 Hemopexin-like repeats
Domain Details Per Protein
Protein Length Hemopexin, conserved site Hemopexin-like domain Hemopexin-like domain superfamily Hemopexin-like repeats Metallopeptidase, catalytic domain superfamily Peptidase M10A Peptidase M10A, catalytic domain Peptidase M10A, cysteine switch, zinc binding site Peptidase M10A, matrix metallopeptidase, C-terminal Peptidase M10, metallopeptidase Peptidase, metallopeptidase Peptidoglycan binding-like PGBD-like superfamily
UniProtKB:Q7T2J2 574
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mmp14a-201 (1) Ensembl 3,509 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-mmp14 polyclonal IgG Rabbit
  • IHC
  • WB
Abcam plc
5
Ab1-mmp14a polyclonal IgG Rabbit
  • IHC
  • WB
AnaSpec
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations