Gene

cflara

ID

ZDB-GENE-030826-3

Name

CASP8 and FADD-like apoptosis regulator a

Symbol

cflara Nomenclature History

Previous Names

cflar
Clarp1 (1)
FLIP (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to localize to cytoplasm. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Sakamaki et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cflara Human Ortholog

No data available

Associated With cflara Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001309	Peptidase C14, p20 domain
Domain	IPR001875	Death effector domain
Domain	IPR011600	Peptidase C14, caspase domain
Domain	IPR015917	Peptidase C14A, caspase catalytic domain
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR029030	Caspase-like domain superfamily