Gene

prmt5

ID

ZDB-GENE-030616-585

Name

protein arginine methyltransferase 5

Symbol

prmt5 Nomenclature History

Previous Names

PRMT5 (1)
si:zc14a17.2
skb1 (1)
wu:fb95f10
zgc:110669

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Enables histone methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Involved in histone H4-R3 methylation and peptidyl-arginine methylation, to symmetrical-dimethyl arginine. Acts upstream of or within regulation of skeletal muscle fiber development. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including heart; liver; pleuroperitoneal region; segmental plate; and shield. Orthologous to human PRMT5 (protein arginine methyltransferase 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prmt5 Human Ortholog

No data available

Associated With prmt5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR035075	PRMT5 arginine-N-methyltransferase
Domain	IPR035247	PRMT5, TIM barrel domain
Domain	IPR035248	PRMT5, oligomerisation domain
Family	IPR007857	Protein arginine N-methyltransferase PRMT5
Family	IPR025799	Protein arginine N-methyltransferase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily

Domain Details Per Protein

Protein	Length	PRMT5 arginine-N-methyltransferase	PRMT5, oligomerisation domain	PRMT5, TIM barrel domain	Protein arginine N-methyltransferase	Protein arginine N-methyltransferase PRMT5	S-adenosyl-L-methionine-dependent methyltransferase superfamily
UniProtKB:Q503E3 InterPro	631

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	prmt5-201 (1) Ensembl	Ensembl		2,459 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB2-prmt5	monoclonal	prmt5		Rabbit	IHC WB		1
Ab1-prmt5	polyclonal	prmt5	IgG	Rabbit	IHC WB	Millipore	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations