Gene
cacna1da
- ID
- ZDB-GENE-030616-135
- Name
- calcium channel, voltage-dependent, L type, alpha 1D subunit, a
- Symbol
- cacna1da Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have high voltage-gated calcium channel activity. Involved in detection of mechanical stimulus involved in sensory perception of sound; neuromuscular process controlling balance; and synapse organization. Localizes to basal plasma membrane and ribbon synapse. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in central nervous system; heart; and neuromast. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
schizophrenia | cacna1dasa17298/+ | standard conditions | Banono et al., 2020 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR005821 | Ion transport domain |
Domain | IPR014873 | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
Domain | IPR031649 | Voltage-dependent L-type calcium channel, IQ-associated domain |
Domain | IPR031688 | Voltage-gated calcium channel subunit alpha, C-terminal |
Family | IPR002077 | Voltage-dependent calcium channel, alpha-1 subunit |
Family | IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit |
Family | IPR050599 | Voltage-dependent calcium channel alpha-1 subunit |
Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
Protein | Length | Ion transport domain | Voltage-dependent calcium channel alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain | Voltage-dependent calcium channel, L-type, alpha-1 subunit | Voltage-dependent channel domain superfamily | Voltage-dependent L-type calcium channel, IQ-associated domain | Voltage-gated calcium channel subunit alpha, C-terminal |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9Q745
|
2054 | ||||||||
UniProtKB:A0A8M9QHK6
|
2068 | ||||||||
UniProtKB:A0A8M9QLJ7
|
2082 | ||||||||
UniProtKB:A0A8M9QD08
|
2057 | ||||||||
UniProtKB:A0A8M9QHK0
|
2093 | ||||||||
UniProtKB:A0A8M9QD03
|
2084 | ||||||||
UniProtKB:A0A8M9PUS4
|
2093 | ||||||||
UniProtKB:A0A8M9Q738
|
2092 | ||||||||
UniProtKB:Q6QRQ2
|
2082 | ||||||||
UniProtKB:A0A8M9PUS9
|
2068 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cacna1da-201
(1)
|
Ensembl | 6,504 nt | ||
mRNA |
cacna1da-202
(1)
|
Ensembl | 6,421 nt | ||
mRNA |
cacna1fb-207
(1)
|
Ensembl | 6,662 nt | ||
mRNA | ottdart00000001787 (1) | Havana | 2,432 nt | ||
mRNA | ottdart00000001972 (1) | Havana | 4,125 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-cacna1da | polyclonal | Rabbit |
|
9 |
Plasmids
No data available