Gene

yars1

ID

ZDB-GENE-030425-2

Name

tyrosyl-tRNA synthetase 1

Symbol

yars1 Nomenclature History

Previous Names

TyrRS (1)
yars
cb204 (1)
wu:fk52b08

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have tyrosine-tRNA ligase activity. Involved in cellular response to DNA damage stimulus. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Is expressed in several structures, including hematopoietic system; immature eye; mesoderm; musculature system; and nervous system. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb204 (17 images)
IMAGE:6910575 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With yars1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease dominant intermediate C	Alliance	Charcot-Marie-Tooth disease, dominant intermediate C	608323
		Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2	619418

Associated With yars1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002547	tRNA-binding domain
Family	IPR002305	Aminoacyl-tRNA synthetase, class Ic
Family	IPR002307	Tyrosine-tRNA ligase
Family	IPR051270	Tyrosine-tRNA ligase and regulatory protein
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold

Domain Details Per Protein

Protein	Length	Aminoacyl-tRNA synthetase, class Ic	Nucleic acid-binding, OB-fold	Rossmann-like alpha/beta/alpha sandwich fold	tRNA-binding domain	Tyrosine-tRNA ligase	Tyrosine-tRNA ligase and regulatory protein
UniProtKB:A0A0R4I9C1 InterPro	529
UniProtKB:Q6TGS6 InterPro	529

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	yars-201 (1) Ensembl	Ensembl	2,445 nt	Select Tool
mRNA	yars-202 (1) Ensembl	Ensembl	898 nt	Select Tool
mRNA	yars-204 (1) Ensembl	Ensembl	309 nt	Select Tool
mRNA	yars-205 (1) Ensembl	Ensembl	838 nt	Select Tool
mRNA	yars-206 (1) Ensembl	Ensembl	753 nt	Select Tool
mRNA	yars1-208 (1) Ensembl	Ensembl	2,463 nt	Select Tool ZFIN BLAST
ncRNA	yars-002 (1) Ensembl	Ensembl	608 nt	Select Tool
ncRNA	yars-003 (1) Ensembl	Ensembl	758 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations