Gene

hkdc1

ID

ZDB-GENE-030131-9801

Name

hexokinase domain containing 1

Symbol

hkdc1 Nomenclature History

Previous Names

cb370 (1)
DrSHXK1 (1)
sb:cb370 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in several processes, including cellular glucose homeostasis; glucose 6-phosphate metabolic process; and phosphorylation. Predicted to act upstream of or within carbohydrate metabolic process and phosphorylation. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including digestive system; endoderm; heart; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human HKDC1 (hexokinase domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb370 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hkdc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Retinitis pigmentosa 92	619614

Associated With hkdc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR019807	Hexokinase, binding site
Domain	IPR022672	Hexokinase, N-terminal
Domain	IPR022673	Hexokinase, C-terminal
Family	IPR001312	Hexokinase
Homologous_superfamily	IPR043129	ATPase, nucleotide binding domain