Gene
ftcd
- ID
- ZDB-GENE-030131-9643
- Name
- formimidoyltransferase cyclodeaminase
- Symbol
- ftcd Nomenclature History
- Previous Names
-
- wu:fp37b11
- zgc:63647
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable folic acid binding activity; formimidoyltetrahydrofolate cyclodeaminase activity; and transferase activity. Predicted to be involved in histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; and tetrahydrofolate interconversion. Predicted to act upstream of or within histidine metabolic process. Located in Golgi apparatus. Is expressed in liver; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148782 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glutamate formiminotransferase deficiency | Alliance | Glutamate formiminotransferase deficiency | 229100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004227 | Formiminotransferase catalytic domain |
| Domain | IPR007044 | Cyclodeaminase/cyclohydrolase |
| Domain | IPR012886 | Formiminotransferase, N-terminal subdomain |
| Domain | IPR013802 | Formiminotransferase, C-terminal subdomain |
| Family | IPR051623 | Formiminotransferase-cyclodeaminase |
| Homologous_superfamily | IPR022384 | Formiminotransferase catalytic domain superfamily |
| Homologous_superfamily | IPR036178 | Formimidoyltransferase-cyclodeaminase-like superfamily |
| Homologous_superfamily | IPR037064 | Formiminotransferase, N-terminal subdomain superfamily |
| Homologous_superfamily | IPR037070 | Formiminotransferase, C-terminal subdomain superfamily |
Domain Details Per Protein
| Protein | Length | Cyclodeaminase/cyclohydrolase | Formimidoyltransferase-cyclodeaminase-like superfamily | Formiminotransferase catalytic domain | Formiminotransferase catalytic domain superfamily | Formiminotransferase, C-terminal subdomain | Formiminotransferase, C-terminal subdomain superfamily | Formiminotransferase-cyclodeaminase | Formiminotransferase, N-terminal subdomain | Formiminotransferase, N-terminal subdomain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PIL2
|
540 |
Interactions and Pathways
No data available
Plasmids
No data available