Gene

fgb

ID

ZDB-GENE-030131-9261

Name

fibrinogen beta chain

Symbol

fgb Nomenclature History

Previous Names

wu:fa55c11

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable signaling receptor binding activity. Acts upstream of or within blood coagulation, fibrin clot formation. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in blood plasma; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77116 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital afibrinogenemia	Alliance	Afibrinogenemia, congenital	202400
congenital afibrinogenemia	Alliance	Hypofibrinogenemia, congenital	202400
		Dysfibrinogenemia, congenital	616004

Associated With fgb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal

Domain Details Per Protein

Protein	Length	Fibrinogen, alpha/beta/gamma chain, coiled coil domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Fibrinogen-like, C-terminal
UniProtKB:Q6NYE1 InterPro	485

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fgb-201 (1) Ensembl	Ensembl	1,835 nt	Select Tool ZFIN BLAST
ncRNA	fgb-002 (1) Ensembl	Ensembl	766 nt	Select Tool ZFIN BLAST
ncRNA	fgb-003 (1) Ensembl	Ensembl	804 nt	Select Tool ZFIN BLAST
ncRNA	fgb-004 (1) Ensembl	Ensembl	760 nt	Select Tool ZFIN BLAST
ncRNA	fgb-005 (1) Ensembl	Ensembl	516 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fgb	polyclonal	fgb		Rabbit	WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations