Gene
prkcea
- ID
- ZDB-GENE-030131-8191
- Name
- protein kinase C, epsilon a
- Symbol
- prkcea Nomenclature History
- Previous Names
-
- prkce
- fj59b07
- wu:fj59b07
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Is expressed in brain; peripheral neurons; and spinal cord. Orthologous to human PRKCE (protein kinase C epsilon).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Patten et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Domain | IPR034669 | Novel protein kinase C epsilon, catalytic domain |
| Family | IPR014376 | Protein kinase C, delta/epsilon/eta/theta types |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | C1-like domain superfamily | C2 domain | C2 domain superfamily | Diacylglycerol/phorbol-ester binding | Novel protein kinase C epsilon, catalytic domain | Protein kinase, ATP binding site | Protein kinase C, delta/epsilon/eta/theta types | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q913
|
742 | |||||||||||||
|
UniProtKB:E7F368
|
744 | |||||||||||||
|
UniProtKB:A0A8M2B2A2
|
743 | |||||||||||||
|
UniProtKB:A0A8M9PX29
|
743 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkcea-201
(1)
|
Ensembl | 4,572 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-prkce | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
1 |
Plasmids
No data available