Gene

atl1

ID

ZDB-GENE-030131-8003

Name

atlastin GTPase 1

Symbol

atl1 Nomenclature History

Previous Names

fj46c01
wu:fj46c01

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have GTP binding activity and GTPase activity. Involved in determination of dorsal identity and negative regulation of BMP signaling pathway. Localizes to late endosome. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D and hereditary spastic paraplegia 3A. Is expressed in brain; primary motor neurons; and spinal cord neural tube. Orthologous to human ATL1 (atlastin GTPase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atl1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory neuropathy type 1D	Alliance	Neuropathy, hereditary sensory, type ID	613708
hereditary spastic paraplegia 3A	Alliance	Spastic paraplegia 3A, autosomal dominant	182600

Associated With atl1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR015894	Guanylate-binding protein, N-terminal
Domain	IPR030386	GB1/RHD3-type guanine nucleotide-binding (G) domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036543	Guanylate-binding protein, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	GB1/RHD3-type guanine nucleotide-binding (G) domain	Guanylate-binding protein, C-terminal domain superfamily	Guanylate-binding protein, N-terminal	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:B8A6H1 InterPro	554
UniProtKB:E9QGX9 InterPro	559

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	atl1-201 (1) Ensembl	Ensembl	1,680 nt	Select Tool ZFIN BLAST
mRNA	atl1-202 (1) Ensembl	Ensembl	2,156 nt	Select Tool
mRNA	atl1-203 (1) Ensembl	Ensembl	407 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-atl1	polyclonal	atl1	IgG	Goat	WB	Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations