Gene

ptpn6

ID

ZDB-GENE-030131-7513

Name

protein tyrosine phosphatase non-receptor type 6

Symbol

ptpn6 Nomenclature History

Previous Names

fj22f05
SHP1 (1)
wu:fj22f05 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have protein tyrosine phosphatase activity. Involved in innate immune response. Predicted to localize to cytoplasm. Is expressed in blood island; macrophage; and thymus. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55501 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptpn6 Human Ortholog

No data available

Associated With ptpn6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR000980	SH2 domain
Domain	IPR003595	Protein-tyrosine phosphatase, catalytic
Family	IPR012152	Protein-tyrosine phosphatase, non-receptor type-6, -11
Family	IPR052123	Non-receptor Tyrosine Phosphatase
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	Non-receptor Tyrosine Phosphatase	Protein-tyrosine phosphatase, active site	Protein-tyrosine phosphatase, catalytic	Protein-tyrosine phosphatase-like	Protein-tyrosine phosphatase, non-receptor type-6, -11	SH2 domain	SH2 domain superfamily	Tyrosine-specific protein phosphatase, PTPase domain	Tyrosine-specific protein phosphatases domain
UniProtKB:Q803M6 InterPro	589
UniProtKB:A0A2R8Q2T0 InterPro	590
UniProtKB:E7F3D4 InterPro	589

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ptpn6-201 (1) Ensembl	Ensembl	2,239 nt	Select Tool ZFIN BLAST
mRNA	ptpn6-202 (1) Ensembl	Ensembl	825 nt	Select Tool ZFIN BLAST
mRNA	ptpn6-203 (1) Ensembl	Ensembl	2,439 nt	Select Tool ZFIN BLAST
mRNA	ptpn6-204 (1) Ensembl	Ensembl	2,833 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ptpn6	polyclonal	ptpn6		Rabbit	WB		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations