Gene

parp3

ID

ZDB-GENE-030131-7435

Name

poly (ADP-ribose) polymerase family, member 3

Symbol

parp3 Nomenclature History

Previous Names

fj17c06
wu:fj17c06
zgc:66157 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable NAD+ poly-ADP-ribosyltransferase activity. Acts upstream of or within ectodermal placode development and regulation of neural crest formation. Predicted to be located in chromosome and nucleus. Predicted to be active in nucleolus and site of double-strand break. Is expressed in axis and notochord. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66157 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Rouleau et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With parp3 Human Ortholog

No data available

Associated With parp3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004102	Poly(ADP-ribose) polymerase, regulatory domain
Domain	IPR008893	WGR domain
Domain	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain
Family	IPR050800	ADP-ribosyltransferase diphtheria toxin-like
Homologous_superfamily	IPR036616	Poly(ADP-ribose) polymerase, regulatory domain superfamily
Homologous_superfamily	IPR036930	WGR domain superfamily