Gene
grnb
- ID
- ZDB-GENE-030131-7393
- Name
- granulin b
- Symbol
- grnb Nomenclature History
- Previous Names
-
- fj14b08
- wu:fj14b08
- zfPGRN-B (1)
- zgc:111858
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Involved in axon extension. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); and neuronal ceroid lipofuscinosis 11. Is expressed in several structures, including central nervous system; gut; immature eye; mesoderm; and pleuroperitoneal region. Orthologous to human GRN (granulin precursor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111858 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Laird et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | Alliance | Aphasia, primary progressive | 607485 |
| Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | Alliance | Frontotemporal dementia 2 | 607485 |
| neuronal ceroid lipofuscinosis 11 | Alliance | Ceroid lipofuscinosis, neuronal, 11 | 614706 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Granulin | Granulin family | Granulin superfamily |
|---|---|---|---|---|
|
UniProtKB:F1R6I2
|
729 | |||
|
UniProtKB:Q7T3M4
|
729 |
Interactions and Pathways
No data available
Plasmids
No data available