Gene

myh9a

ID
ZDB-GENE-030131-5870
Name
myosin, heavy chain 9a, non-muscle
Symbol
myh9a Nomenclature History
Previous Names
  • myh9
  • myh9l2
  • fi22c04
  • fj85e11
  • wu:fi22c04 (1)
  • wu:fj85e11
  • zgc:162029 (1)
  • zNMHC-IIA (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to myosin complex. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal failure; and proteinuria. Is expressed in several structures, including epidermis; nervous system; periderm; pronephric duct opening; and tail bud. Orthologous to human MYH9 (myosin heavy chain 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myh9a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 17 Alliance Deafness, autosomal dominant 17 603622
MYH-9 related disease Alliance Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 155100
Associated With myh9a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M2BCY6 1954
UniProtKB:A0A8M9PLW1 997
UniProtKB:A0A8M1NEM1 1961
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA myh9a-201 (1) Ensembl 3,017 nt
mRNA myh9a-202 (1) Ensembl 6,842 nt
mRNA myh9a-204 (1) Ensembl 1,056 nt
mRNA myh9a-205 (1) Ensembl 2,850 nt
ncRNA myh9a-002 (1) Ensembl 791 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-myh9 polyclonal Rabbit
  • IHC
  • WB
Covance
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations