Gene
vcp
- ID
- ZDB-GENE-030131-5408
- Name
- valosin containing protein
- Symbol
- vcp Nomenclature History
- Previous Names
-
- CDC48 (1)
- wu:fd16d05
- wu:fj63d11
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ATPase activity and polyubiquitin modification-dependent protein binding activity. Involved in chordate embryonic development; locomotory behavior; and regulation of cellular catabolic process. Predicted to localize to several cellular components, including VCP-NPL4-UFD1 AAA ATPase complex; cytosol; and site of double-strand break. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Is expressed in brain; lens; liver; and trunk musculature. Orthologous to human VCP (valosin containing protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56043 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2Y | Alliance | Charcot-Marie-Tooth disease, type 2Y | 616687 |
| frontotemporal dementia and/or amyotrophic lateral sclerosis 6 | Alliance | Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 | 613954 |
| inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 | Alliance | Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia 1 | 167320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003338 | CDC48, N-terminal subdomain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR004201 | CDC48, domain 2 |
| Domain | IPR015415 | Spastin/Vps4, C-terminal |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR005938 | AAA ATPase, CDC48 family |
| Family | IPR050168 | AAA ATPase domain-containing protein |
| Homologous_superfamily | IPR009010 | Aspartate decarboxylase-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR029067 | CDC48 domain 2-like superfamily |
Domain Details Per Protein
| Protein | Length | AAA ATPase, AAA+ lid domain | AAA ATPase, CDC48 family | AAA+ ATPase domain | AAA ATPase domain-containing protein | Aspartate decarboxylase-like domain superfamily | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | CDC48, domain 2 | CDC48 domain 2-like superfamily | CDC48, N-terminal subdomain | P-loop containing nucleoside triphosphate hydrolase | Spastin/Vps4, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZU99
|
806 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vcp-201
(1)
|
Ensembl | 3,041 nt | ||
| ncRNA |
vcp-004
(1)
|
Ensembl | 594 nt | ||
| ncRNA |
vcp-006
(1)
|
Ensembl | 418 nt | ||
| ncRNA |
vcp-007
(1)
|
Ensembl | 686 nt | ||
| ncRNA |
vcp-008
(1)
|
Ensembl | 671 nt | ||
| ncRNA |
vcp-009
(1)
|
Ensembl | 703 nt | ||
| ncRNA |
vcp-010
(1)
|
Ensembl | 697 nt | ||
| ncRNA |
vcp-011
(1)
|
Ensembl | 598 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-vcp | polyclonal | IgG | Rabbit |
|
Novus Biologicals, LLC
|
2 |
Plasmids
No data available