Gene
tgif1
- ID
- ZDB-GENE-030131-475
- Name
- TGFB-induced factor homeobox 1
- Symbol
- tgif1 Nomenclature History
- Previous Names
-
- fa06h05
- fb33g11
- wu:fa06h05
- wu:fb33g11
- zgc:55852
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity. Involved in several processes, including brain development; regulation of signal transduction; and sensory epithelium regeneration. Predicted to localize to nucleus. Used to study holoprosencephaly. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Is expressed in several structures, including forebrain neural plate; neural tube; presumptive diencephalon; retinal neural layer; and spinal cord neural keel. Orthologous to human TGIF1 (TGFB induced factor homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55852 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| holoprosencephaly 4 | Alliance | Holoprosencephaly 4 | 142946 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| holoprosencephaly | WT + MO1-tgif1 | standard conditions | Gongal et al., 2008 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeodomain | KN homeodomain | Three Amino acid Loop Extension (TALE) homeobox |
|---|---|---|---|---|---|
|
UniProtKB:Q803F0
|
273 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tgif1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
1 |
Plasmids
No data available