Gene
ttpa
- ID
- ZDB-GENE-030131-4631
- Name
- tocopherol (alpha) transfer protein
- Symbol
- ttpa Nomenclature History
- Previous Names
-
- wu:fd44e05
- zgc:66361
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Acts upstream of or within central nervous system development and chordate embryonic development. Predicted to be active in late endosome. Is expressed in several structures, including immature eye; liver; nervous system; tail bud; and yolk syncytial layer. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66361 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Miller et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial isolated deficiency of vitamin E | Alliance | Ataxia with isolated vitamin E deficiency | 277460 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | CRAL/TRIO, N-terminal domain | CRAL/TRIO, N-terminal domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:B0S5J5
|
285 |
Interactions and Pathways
No data available
Plasmids
No data available